![]() The PRAC further considered that the risks of effects on the heart and circulation, and any potential mechanisms for such effects should continue to be monitored, and information from ongoing studies should be provided as part of the next regular safety review (to which these medicines, like all medicines in the EU, are subject). ![]() Testosterone levels naturally fall somewhat with age, but restoration of these levels in healthy older men is not an authorised use of the medicine in the EU. The product information should make it clear that testosterone should only be used when an abnormally low level of the hormone has been confirmed by signs and symptoms and appropriate laboratory tests. The PRAC recommended updating the product information in line with the latest evidence and to provide warnings about those who might be at increased risk of heart problems. The PRAC also noted that the lack of testosterone itself could increase the risk of heart problems. The PRAC considered these studies along with available data from other studies and analyses, and information on safety collected since marketing, and found that the evidence regarding the risk of heart problems was inconsistent: some studies suggested increased risk, while others did not, and some of the studies had problems with the design that limited the conclusions that could be drawn from them. The review was started because of some recent studies suggesting an increase in heart problems in men using testosterone, compared with men not using it. The CMDh position follows a review by the EMA's Pharmacovigilance Risk Assessment Committee ( PRAC) which looked at the risk of serious problems affecting the heart and circulation, particularly heart attacks, in men treated with these medicines. However, the product information is to be updated in line with the most current available evidence on safety, and with warnings that the lack of testosterone should be confirmed by signs and symptoms and laboratory tests before treating men with these medicines. This test is the gold standard for diagnosing heart disease in cats.The Coordination Group for Mutual Recognition and Decentralised Procedures – Human ( CMDh), a regulatory body representing EU Member States, has agreed by consensus that there is no consistent evidence of an increased risk of heart problems with testosterone medicines in men who lack the hormone (a condition known as hypogonadism). Echocardiogram – ultrasound by a board-certified vet cardiologist to view your cat’s heart in great detail.Electrocardiogram (ECG) – to measure electrical activity of your cat’s heart to find heart rhythm problems.NT-proBNP – blood test that measures a heart stress hormone thet can help detect heart disease. ![]() Physical exam – including listening to the heart and lungs, checking your cat’s blood pressure.Give us a call, and we will set up one or all of the following: CVCA has several locations in Maryland, Kentucky, Texas, and Virginia. If you have concerns about your cat and heart disease, it’s best to reach out to a pet cardiologist near you to get a clear diagnosis and treatment plan. When caught early, this disease can be treated to improve the quality and duration of life in affected cats. This is a genetic-based disease that causes the heart muscle to become too thick. Hypertrophic Cardiomyopathy in Catsīy far, the single most common heart problem that affects cats is hypertrophic cardiomyopathy or HCM. CVCA Cardiac Care for Pets is one of the few veterinary practices with board-certified veterinary cardiologists on staff. ![]() If your veterinarian finds a heart problem or your cat is showing signs of heart disease, it’s best to talk with a board-certified cat cardiologist. If it’s late in the course of the disease, then a cat might show signs of disease - such as faster breathing, weakness, or hiding. However, many cats have a silent disease that can only be found by a blood test - NT ProBNP. A cat with heart disease might have a heart murmur or rhythm problem that your veterinarian would hear. Heart disease affects 15% of all cats and is difficult to detect. ![]()
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